The goal of IVF treatment is to ensure that the patient has children as soon as possible. However, the success rate in the first application is only 30 - 35 percent. Eurofertil Gynecology and Obstetrics Specialist Dr. Contact Hakan directly “Some laboratory techniques are really giving good results to increase these rates,” he explains about the new methods.
It is ideal for the IVF to become pregnant during the first treatment period. However, even in the best centers in the world, the pregnancy rate is 30-35%. Many scientific studies are being conducted to increase this ratio. Some of the currently used laboratory techniques are indeed giving promising results to increase these rates. These methods are:
In order for the fertilized egg to hold the embryo in the uterus, the outer shell must be torn off. Assisted hatching is the aid of tearing the egg's shell to facilitate its placement in the uterus. It is a method that is useful only for patients in need. These; those with thick eggshells, cases to be transferred to frozen embryos, those with recurrent IVF failure, and patients over 40 years of age. Technically, the shell can be mechanically torn or chemically torn with the aid of a melting liquid. Another technique developed in recent years is the creation of tears with the help of laser.
The most important part of IVF treatment is the laboratory part. Advances here have a direct impact on pregnancy rates. Developments in embryos where they live outside the body now allow us to keep them outside the body for longer. In this way, more advanced embryos can be transferred, which means increased pregnancy rates. Why are pregnancy rates rising? There are multiple reasons for this; Embryos living up to the 5th or 6th day are more likely to survive, and the normal embryo enters the uterus on the 6th day, which means that this procedure is closer to nature. All of these increase pregnancy rates, so the number of embryos to be given is reduced, ie multiple pregnancies are reduced. This means reaching the highest pregnancy rate with the least embryo, which is the basic philosophy of IVF.
Advances in cell biology have now allowed the human embryo to be frozen without damage. Embryo frozen with the help of special devices can be stored in tanks containing liquid nitrogen at -196 ° C without losing its viability for years. The biggest advantages of using frozen embryos are; In the treatment periods when the embryo is thawed and transferred, the woman does not receive an extra hormone treatment that improves the eggs and there is no need for egg collection operation and sperm. Thus, the patient is protected from possible complications that may occur during egg collection and hormone treatment. The chances of pregnancy by frozen embryos transfer after thawing are slightly lower than those of fresh embryo transfer, but the price of frozen embryo transfer is much cheaper than a full IVF treatment.
When excess embryos are obtained during in vitro fertilization, non-transferred embryos are stored frozen. If embryos do not occur during pregnancy, these embryos can be thawed in later trials. For such a trial, there must be at least 2 frozen embryos.